Intravenous treatment originated in the 19th century, and the 19th century was the century of great medical development. The first great achievement was in 1818, when James Blundell performed the first human-to-human blood transfusion in London. In 1834, Blundell re-transmitted blood from person to person. The recipient of the blood transfusion was a woman who was dying due to bleeding. Therefore, Blundell further believed that the blood loss caused by bleeding was related to low blood volume.